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DJ-1 monoclonal antibody (3E8)

ADI-KAM-SA100-E 100 µg 307.00 USD
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Product Specification

Alternative Name:PARK7, Parkinson disease protein 7
Immunogen:Recombinant human DJ-1.
UniProt ID:Q99497
GenBank ID:BAA09603
Species reactivity:Human
Recommended Dilutions/Conditions:Western Blot (1-10 µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects bands of ~28kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Researchers cloned DJ-1 protein, consisting of 189 amino acids, from a HeLa cell cDNA library as a oncogene which weakly transformed NIH3T3 cells. Cotransfection with ras or c-myc enhances transformation by DJ-11. DJ-1 expression is induced by growth signals, and it is translocated from the cytoplasm to the nucleus during the S phase without the presence of any nuclear localization signals. In addition to its potential involvement in ras-mediated signal transduction pathways, DJ-1 is known to regulate transcription of androgen-responsive genes, and is sensitive to oxidative stress. DJ-1 is ubiquitously expressed in various human tissues including the brain, with high expression in astrocytes of the frontal cortex and substantia nigra. Homozygous mutations in the DJ-1 gene have been shown to cause early-onset autosomal recessive Parkinson’s disease.
Western blot analysis of Jurkat (1), Raji (2), HeLa (3), NIH/3T3 (4) and PC12 (5) using DJ-1 mAb (3E8).
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Product Literature References

DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia: P. Rizzu, et al.; Ann. Neurol. 55, 138 (2004), Abstract;
Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer: S.M. Hanash, et al. ; Clin. Cancer Res. 7, 3328 (2001), Application(s): WB using human samples, Abstract;

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