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MEK1 monoclonal antibody (4A5)

 
ADI-KAM-MA300-E 100 µg 269.00 USD
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Product Specification

Alternative Name:MKK1, MAP kinase kinase 1
 
Clone:4A5
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Recombinant Xenopus MEK1.
 
UniProt ID:Q05116
 
Species reactivity:Human, Rat
Xenopus
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (50µl cell extract, 5-10µg/ml)
Western Blot (1-5µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis.
 
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