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[pSer780]Rb monoclonal antibody (2C4)

 
ADI-KAM-CP121-E 100 µg 291.00 USD
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Product Specification

Alternative Name:Retinoblastoma-associated protein
 
Clone:2C4
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to a portion of human Rb phosphorylated at Ser780.
 
UniProt ID:P06400
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Lyophilized. In PBS, pH 7.2, containing 1% sucrose. No preservatives. For a stock solution of 1.0mg/ml reconstitute with 100μl of sterile distilled water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The Retinoblastoma (Rb) is a tumor suppressor phosphoprotein that plays a critical role in the regulation of the cell cycle. In the absence of mitogenic signaling, Rb sequesters the transcription factor E2F within the cytosol. Upon phosphorylation, E2F is liberated from Rb and translocates to the nucleus where the latter facilitates gene transcription. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
 
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Retinoblastoma protein
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