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[pSer139]Histone H2AX monoclonal antibody (9F3)

 
ADI-KAM-CC255-D 50 µg 194.00 USD
 
ADI-KAM-CC255-F 200 µg 443.00 USD
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Product Specification

Clone:9F3
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Synthetic peptide corresponding to a portion of human Histone H2AX phosphorylated at Ser139.
 
UniProt ID:P16104
 
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~16kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.
 
Technical Info/Product Notes:Patents: USPN 6,362,317 and 6,884,873
 
ADI-KAM-CC255 WB
Western blot analysis of [pSer139] Histone H2AX, mAb (9F3) (Prod. No. ADI-KAM-CC255): Lane 1: MW marker; Lane 2: Jurkat cell lysate; Lane 3: Jurkat cell lysate treated with staurosporine; Lane 4: 3T3 cell lysate; Lane 5: CHO-K1 cell lysate; Lane 6: Rat-2 cell lysate.
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ADI-KAM-CC255 WB

Product Literature References

The bipartite Rac1 guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) protects endothelial cells from apoptosis in blood vessel development: K. Schaeker, et al.; J. Biol. Chem. 290, 6408 (2015), Application(s): Western Blotting, Abstract; Full Text

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