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ORC2 monoclonal antibody (3B7)

ADI-KAM-CC235-E 100 µg 307.00 USD
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Product Specification

Alternative Name:Origin recognition complex subunit 2
Immunogen:Recombinant human ORC2.
UniProt ID:Q13416
Species reactivity:Human
Applications:ICC, IP, WB
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Immunoprecipitation (5µg/ml)
Western Blot (1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~67kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:DNA replication in Saccharomyces cerevisiae initiates from specific DNA sequences called autonomous replication sequences (ARSs), many of which have proven to be chromosomal origins of replication. The six subunit origin recognition complex (ORC) was identified initially by its ARSs binding activity in an ATP-dependent manner. ORC functions as a recruiter of cofactors such as Mcms to origins, and may also play a role in transcriptional silencing. ORC2 is the second largest subunit of the ORC but its specific function in eukaryotic cells remains unclear. In yeast, ORC2 is involved in suppression of late origins.
Western blot analysis: Jurkat (1), Raji (2), JepG2 (3), HeLa (4), U937 (5), NIH3T3 (6), WR19L (7) cell lysates, probed with ORC2 mAb (3B7).
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Product Literature References

Caspase-mediated cleavage of importin-α increases its affinity for MCM and downregulates DNA synthesis by interrupting the binding of MCM to chromatin: H. Lee, et al. ; Biochim. Biophys. Acta 1783, 2287 (2008), Application(s): WB, IP , Abstract;

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