Product Specification
Alternative Name: | RCC1 |
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Clone: | 3D11 |
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Host: | Mouse |
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Isotype: | IgG1 |
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Immunogen: | Recombinant human RanGEF. |
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UniProt ID: | P18754 |
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Species reactivity: | Human, Mouse, Rat
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Applications: | ICC, IP, WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (5µg/ml) Immunoprecipitation (2µg/ml) Western Blot (1µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~45kDa by Western blot. |
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Purity Detail: | Protein A affinity purified. |
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Formulation: | Lyophilized. In PBS, pH 7.2, containing 1% sucrose. No preservatives. For a stock solution of 1.0mg/ml, reconstitute with 100mg/ml of sterile distilled water. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | RanGEF, also known as regulator of chromosome condensation (RCC1), is an abundant, highly conserved chromatin-associated 45 kDa protein. RanGEF is involved in the regulation of the onset of chromosome condensation in the S phase, and is the principle mammalian guanine nucleotide exchange factor (GEF) for the nuclear G protein Ran. RanGEF plays important roles in RNA transcription and processing, DNA replication, nuclear pore transport function, and cell cycle regulation. |
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Western blot analysis of RanGEF probed with RanGEF (RCC1), mAb (3D11).
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For Research Use Only. Not for use in diagnostic procedures.