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DNA-topoisomerase II α/β monoclonal antibody (AK5)

 
ADI-KAM-CC215-E 100 µg 301.00 USD
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Product Specification

Clone:AK5
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human DNA-topoisomerase IIα (N-terminal fragment).
 
UniProt ID:P11388 (α isozyme), Q02880 (β isozyme)
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (5-10µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.
 
KAM-CC215 WB
Western blot analysis of Jurkat (1,3) and Raji (2,4) cell lysates, probed with Topo IIa/β at 5µg/ml (1,2), and 10µg/ml (3,4).
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KAM-CC215 WB

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