Cullin 1, mAb (AS97.1)

Alternative Name:	CUL1

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 0.1mM PMSF and 50% glycerol.

Clone:	AS97.1

Isotype:	Mouse IgG2a

Immunogen:	Recombinant human cullin 1.

Specificity:	Recognizes human, mouse, rat, bovine, monkey and rabbit Cullin 1. Detects a band of ~93kDa by Western blot.

Application:	Western Blot (1:250, ECL) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	The human Cullin family of genes consists of Cul-1, Cul-2, Cul-3, Cul-4a, Cul-4b, and Cul-5. Among the 6 members, Cul-1 and Cul-2 are very well characterized. Cul-2 is homologous to the Saccharomyces cerevisiae cdc53 gene. Studies have shown that Cul-1 forms an E3 ubiquitin-ligase, called the SCF complex (Skp1 and F-box protein such as bTrCp or FWD1), which controls the proteolysis of G1 cell cycle regulatory proteins.