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14-3-3 β/ζ monoclonal antibody (22-ii-D8B)

 
ADI-KAM-CC012-C 25 µg 118.00 USD
 
ADI-KAM-CC012-E 100 µg 258.00 USD
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Product Specification

Alternative Name:Protein kinase C inhibitor protein, Protein 1054
 
Clone:22-ii-D8B
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Lysed transformed human amnion cells (AMA).
 
UniProt ID:P31946 (14-3-3 beta), P63104 (14-3-3 zeta)
 
Gene/Protein Identifier:NP_003395 (RefSeq of 14-3-3 beta), NP_663723 (RefSeq of 14-3-3 zeta)
 
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Monkey, Porcine, Rabbit, Sheep
 
Applications:ICC, IHC, WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.1mM PMSF, 50% glycerol, and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:14-3-3 proteins are highly conserved proteins that play a role in both signal transduction and progression through the cell cycle by binding to and regulating a number of different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms.
 
KAM-CC012-Antibody-Blot
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KAM-CC012-Antibody-Blot

Product Literature References

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2: W. Wasco, et al. ; J. Biol. Chem. 276, 19197 (2001), Application(s): WB using monkey samples, Abstract;

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