14-3-3 β/ζ, mAb (22-ii-D8B)



ADI-KAM-CC012-C	25 µg	110.00 USD

ADI-KAM-CC012-E	100 µg	235.00 USD

Product Specification

Alternative Name:	Protein kinase C inhibitor protein, Protein 1054

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 0.1mM PMSF, 50% glycerol, and 0.09% sodium azide.

Clone:	22-ii-D8B

Isotype:	Mouse IgG

Immunogen:	Lysed transformed human amnion cells (AMA).

Specificity:	Recognizes human, mouse, rat, bovine, dog, monkey, pig, rabbit and sheep 14-3-3 β/ζ.

Application:	Immunocytochemistry Immunohistochemistry Western Blot (1µg/ml, ECL) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	14-3-3 proteins are highly conserved proteins that play a role in both signal transduction and progression through the cell cycle by binding to and regulating a number of different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms.

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Product Literature References

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2: W. Wasco, et al. ; J. Biol. Chem. 276, 19197 (2001), Application(s): WB using monkey samples, Abstract;