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CENP-A monoclonal antibody (3-19)

 
ADI-KAM-CC006-E 100 µg 323.00 USD
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Product Specification

Alternative Name:Centromere protein A
 
Clone:3-19
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to a portion of human CENP-A .
 
UniProt ID:P49450
 
Species reactivity:Human
 
Applications:ICC, IHC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Immunohistochemistry (5µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects bands of ~18kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Centromere protein A (CENP-A), a 17-19 kDa centromere-specific histone variant, is 62% identical to the carboxy-terminal domain of histone H3.  In the presence of DNA, CENP-A forms an octameric complex with histones H4, H2A, and H2B.  CENP-A defines active centromere regions by forming centromere-specific nucleosomes on which kinetochores are assembled.  CENP-A resides specifically in the inner plate of the kinetochore, and is essential for kinetochore targeting of CENP-C and other kinetochore components.  CENP-A is required for nucleosomal packaging of centromeric DNA at interphase.
 
KAM-CC006 WB
Western blot analysis of Jurkat (1), Raji (2), PC12 (3), Rat-1 (4), WR19L (5), C2C12 (6), and NIH3T3 (7) cell lysates probed with CENP-A mAb (3-19).
KAM-CC006 IHC
Immunohistochemical detection of CENP-A on paraffin embedded section of a squamous epithelium of human tonsil.
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KAM-CC006 WB KAM-CC006 IHC

Product Literature References

Composition and organization of active centromere sequences in complex genomes: K.E. Hayden, et al.; BMC Genomics 13, 324 (2012), Abstract; Full Text

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