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TNF receptor 1 polyclonal antibody

 
ADI-CSA-815-D 50 µg 205.00 USD
 
ADI-CSA-815-F 200 µg 399.00 USD
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Product Specification

Alternative Name:Tumor necrosis factor receptor 1, TNF-R1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of mouse TNF-R1. The sequence is completely conserved in rat and human.
 
UniProt ID:P25118
 
GenBank ID:X59238
 
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus, Yeast
 
Applications:IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (12.5µg/ml)
Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of 55kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.
 
CSA-815 WB
Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat
CSA-815 IHC
Immunohistochemistry analysis of human spleen tissue stained with TNF receptor 1 pAb at 10µg/ml.
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CSA-815 WB CSA-815 IHC

Product Literature References

Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo: H. Yamawaki, et al.; Circulation 108, 1619 (2003), Application(s): IP, WB using rabbit samples, Abstract;

General Literature References

TNF-R1 signaling: a beautiful pathway: G. Chen & D.V. Goeddel; Science 296, 1634 (2002), Abstract;
Induction of Jak/STAT signaling by activation of the type 1 TNF receptor: D. Guo, et al.; J. Immunol. 160, 2742 (1998), Abstract;
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38: T. Yuasa, et al.; J. Biol. Chem. 273, 22681 (1998), Abstract;
A novel domain within the 55 kd TNF receptor signals cell death: L.A. Tartaglia, et al.; Cell 74, 845 (1993), Abstract;
Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences: Z. Dembic, et al.; Cytokine 2, 231 (1990), Abstract;

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