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TAP1 polyclonal antibody

 
ADI-CSA-620-E 100 µl 306.00 USD
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Product Specification

Alternative Name:Transporter Associated with Antigen Processing 1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human TAP1 .
 
UniProt ID:Q03518
 
Source:Purified from rabbit serum.
 
Species reactivity:Human, Rat
 
Applications:IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:100)
Western Blot (ECL, 1:1,000-1:4000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~70kDa by Western blot.
 
Formulation:Liquid. Whole rabbit serum.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:TAP1 and TAP2 are two structurally related subunits of the Transporter associated with antigen processing (TAP). The TAP complex is a member of the ATP binding cassette (ABC) family of transmembrane transporters. The TAP transporter is an essential component of the MHC class I antigen presentation pathway by binding peptides in its cytosolic part and subsequently translocating the peptides into the lumen of the endoplasmic reticulum where assembly of MHC class I and pepide takes place.
 
TAP1 polyclonal antibody Immunohistochemistry
IHC Analysis: Human uterus tissue stained with TAP1, pAb at 1:100.
TAP1 polyclonal antibody Immunohistochemistry
IHC Analysis: Human prostate tissue stained with TAP1, pAb at 1:100.
TAP1 polyclonal antibody Immunohistochemistry
IHC Analysis: Human tonsil tissue stained with TAP1, pAb at 1:100.
TAP1 polyclonal antibody Western blot
Western blot analysis of TAP1, pAb (Prod. No. ADI-CSA-620): Lane 1: MW marker, Lane 2: A431 cell lysate Lane 3: HeLa cell lysate (Prod. No. ADI-LYC-HL100)
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TAP1 polyclonal antibody Immunohistochemistry TAP1 polyclonal antibody Immunohistochemistry TAP1 polyclonal antibody Immunohistochemistry TAP1 polyclonal antibody Western blot

Product Literature References

Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors: K. Hirabayashi, et al.; Anticancer Res. 38, 2227 (2018), Abstract;
HLA-G peptide preferences change in transformed cells: impact on the binding motif: A.A. Celik, et al.; Immunogenetics 70, 485 (2018), Abstract;
WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study: R. Yanagisawa, et al.; Anticancer Res. 38, 2217 (2018), Abstract;
Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer: T. Shen, et al.; Oncotarget 8, 60975 (2017), Abstract;
Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes: S. Badrinath, et al.; Haematologica 97, 98 (2012), Abstract; Full Text
MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding: P. Cresswell, et al. ; Nature 368, 864 (1994), Application(s): IP using human samples, Abstract;

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