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COX-2 monoclonal antibody (AS73)

 
ADI-COX-035-E 100 µg 300.00 USD
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Product Specification

Alternative Name:Cyclooxygenase 2, Prostaglandin H synthase 2
 
Clone:AS73
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human COX-2 (cyclooxygenase-2).
 
UniProt ID:P35354
 
Species reactivity:Rat
 
Applications:ELISA
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 0.08% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Cyclooxygenases-1 and 2 (COX-1 and COX-2) also known as Prostaglandin endoperoxide H synthases-1 and 2 are integral membrane proteins which catalyze the first step of Prostaglandin, Thromboxane, and Procastacyclin production from Arachidonic acid. The COX-1 and COX-2 enzymes are important pharmacologically as targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen and the COX-2 inhibitors. Inhibition of Cyclooxygenases with NSAIDs acutely reduces inflammation, pain, and fever.
 

Product Literature References

The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β: M. Adzic, et al.; Behav. Brain Res. 291, 130 (2015), Application(s): Western Blot, Abstract;

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