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Agrin monoclonal antibody (Agr-131)

ADI-AGR-530-D 50 µg 209.00 USD
ADI-AGR-530-F 200 µg 397.00 USD
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Product Specification

Immunogen:Recombinant rat agrin (C-terminal fragment).
UniProt ID:P25304
GenBank ID:M64780
Species reactivity:Mouse, Rat
Applications:ICC, IHC (PS), WB
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~100kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development. Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation.
AGR-530 schematic
The diagram indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.
Immunohistochemistry analysis of rat brain tissue using Agrin, mAb (Agr-131) ( ADI-AGR-530).
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AGR-530 schematic ADI-AGR-530 IHC

Product Literature References

Aggregation of sodium channels induced by a postnatally upregulated isoform of agrin: J.H. Caldwell, et al. ; J. Neurosci. 16, 6775 (1996), Application(s): ICC using rat samples, Abstract;
Agrin acts via a MuSK receptor complex: G.D. Yancopoulos, et al. ; Cell 85, 513 (1996), Application(s): Micro Array, WB using mouse samples, Abstract;
Neural agrin activates a high-affinity receptor in C2 muscle cells that is unresponsive to muscle agrin: Z.W. Hall, et al. ; J. Neurosci. 16, 3791 (1996), Application(s): Other using rat samples, Abstract;

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