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Smac/DIABLO polyclonal antibody

 
ADI-AAP-465-E 100 µl 230.00 USD
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Product Specification

Alternative Name:Second mitochondria-derived activator of caspase
 
Host:Rabbit
 
Immunogen:Recombinant human Smac/DIABLO .
 
UniProt ID:Q9NR28
 
Gene/Protein Identifier:NM_019887 (RefSeq)
 
Species reactivity:Human, Mouse, Rat
Hamster
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1-2µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.
 

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