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RICK polyclonal antibody

 
ADI-AAP-460-E 100 µg 356.00 USD
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Product Specification

Alternative Name:RIP2, CARDIAK, CARD-containing interleukin-1β converting enzyme associated kinase, RIPK2, Receptor-interacting serine/threonine protein kinase 2, Receptor-interacting protein 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human RICK.
 
UniProt ID:O43353
 
GenBank ID:AF027706
 
Species reactivity:Human, Mouse, Rat
 
Applications:ICC, IP, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Western Blot (0.5-1.0µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:-20°C
 
Scientific Background:The RICK (Receptor-interacting serine/threonine protein kinase 2) protein, also known as RIP-like interacting CLARP kinase, and CARD-containing ICE associated kinase, contains an N-terminal kinase domain and a C-terminal CARD domain. Overexpression of RICK results in the activation of NF-κB pathway and also induces apoptosis. RICK represents a kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1beta.
 
AAP-460 WB
Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.
AAP-460 ICC
Immunocytochemistry analysis of RICK in A431 cells with RICK antibody at 10µg/ml.
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AAP-460 WB AAP-460 ICC

Product Literature References

A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2: M.V. Chao, et al. ; J. Neurosci. 21, 5854 (2001), Application(s): IP using rat samples, Abstract;

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