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DFF45/ICAD polyclonal antibody

 
ADI-AAP-451-E 100 µg 340.00 USD
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Product Specification

Alternative Name:CAD
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse DFF45.
 
UniProt ID:O54786
 
GenBank ID:AB009376, AB009375
 
Species reactivity:Mouse
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (2µg/ml)
Western Blot (1µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects bands of ~43-47kDa (ICADL) and ~28kDa (ICADS) by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Human DNA fragmentation fragment (DFF) 45 and its mouse homologue caspase activated deoxyribonuclease (ICAD) are the inhibitors of DFF40 and CAD, respectively. DFF is composed of two subunits, DFF40/CAD and DFF45/ICAD. Cleavage of DFF45/ICAD, which is mediated by caspase-3, leads to DFF40/CADs activation as a nuclease. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death. DFF40 mRNA is expressed in a limited number of human tissues; pancreas, spleen, prostate, and ovary.
 
AAP-451 WB
Western blot analysis of ICAD in mouse lung tissue lysate with ICAD antibody at 1µg/ml.
AAP-451 IHC
Immunohistochemistry analysis of ICAD in mouse lung tissue with ICAD antibody at 2µg/ml.
Please mouse over
AAP-451 WB AAP-451 IHC

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