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c-FLIP polyclonal antibody

 
ADI-AAP-440-E 100 µg 356.00 USD
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Product Specification

Alternative Name:CASPER, CLARP, I-FLICE, Usurpin
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human c-FLIP6. The sequence conserved among all c-FLIP variants.
 
UniProt ID:O15519
 
GenBank ID:U97074, U97075
 
Species reactivity:Human, Mouse, Rat
 
Applications:ICC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (5µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~28-58kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The cellular FLICE-like inhibitory protein, cFLIP, is a cellular homologue of the viral protein, vFLIP. cFLIP contains two death effector domains (DEDs) and is expressed as either a short or long splice variant called cFLIPs and cFLIPL, respectively. cFLIP acts as a caspase-8 dominant negative regulator, blocking apoptosis induced by the oligimerization of the adapter protein, FADD. cFLIP interacts with FADD and caspase-8 through their respective DEDs.
 
AAP-440 WB
Western blot analysis of FLIP in K562 cell lysate with FLIP antibody at (A) 1 and (B) 2µg/ml.
AAP-440 ICC
Immunocytochemistry analysis of FLIP in HeLa cells with FLIP antibody at 5µg/ml.
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AAP-440 WB AAP-440 ICC

Product Literature References

5 Fluorouracil Preferentially Sensitizes Mutant KRAS Non-Small Cell Lung Carcinoma Cells to TRAIL-Induced Apoptosis: H. Wang, et al.; Mol. Oncol. 9, 1815 (2015), Application(s): Western Blot, Abstract; Full Text
Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells: S. Seah, et al.; Cell Death Dis. 6, e1926 (2015), Application(s): Western Blot, Abstract; Full Text
Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL: J. Sun, et al.; Int. J. Clin. Exp. Pathol. 8, 6519 (2015), Application(s): Western blot , Abstract; Full Text

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