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DFF40/CAD polyclonal antibody

 
ADI-AAP-350-E 100 µg 347.00 USD
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Product Specification

Alternative Name:ICAD
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the middle of mouse DFF40/CAD.
 
UniProt ID:O54788
 
GenBank ID:AB009377
 
Species reactivity:Mouse, Rat
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (2µg/ml)
Western Blot (1-4µg/ml, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~43kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Human DNA fragmentation fragment (DFF) 45 and its mouse homologue caspase activated deoxyribonuclease (ICAD) are the inhibitors of DFF40 and CAD, respectively. DFF is composed of two subunits, DFF40/CAD and DFF45/ICAD. Cleavage of DFF45/ICAD, which is mediated by caspase-3, leads to DFF40/CADs activation as a nuclease. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death. DFF40 mRNA is expressed in a limited number of human tissues; pancreas, spleen, prostate, and ovary.
 
AAP-350 WB
Western blot analysis of CAD in mouse kidney tissue lysate with CAD antibody at 2µg/ml.
AAP-350 IHC
Immunohistochemistry analysis of CAD in mouse kidney tissue with CAD antibody at 2µg/ml.
Please mouse over
AAP-350 WB AAP-350 IHC

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