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Survivin polyclonal antibody

 
ADI-AAP-275-E 100 µg 366.00 USD
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Product Specification

Alternative Name:BIRC5, EPR1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human Survivin.
 
UniProt ID:O15392
 
Species reactivity:Human, Mouse
Drosophila
 
Applications:ICC, WB
 
Recommended Dilutions/Conditions:Western Blot (0.5-1.0µg/ml, colorimetric)
Immunocytochemistry (5µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~17kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or non-detectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase-3 and Caspase-7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivin epitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosis-based cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy.
 
AAP-275 WB
Western blot analysis of Survivin in MOLT4 cell lysate with Survivin antibody at (A) 1 and (B) 2µg/ml.
AAP-275 ICC
Immunocytochemistry analysis of Survivin in Jurkat cells with Survivin antibody at 5µg/ml.
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AAP-275 WB AAP-275 ICC

Product Literature References

Glycogen Synthase Kinase 3β-Mediated Serine Phosphorylation ofthe Human Glucocorticoid Receptor Redirects Gene Expression Profiles: J. Cidlowski, et al. ; Mol. Cell. Biol. 28, 7309 (2008), Application(s): WB using human & mouse cell lysates, Abstract;
Rapid cold-hardening protects Drosophila melanogaster from cold-induced apoptosis: R.E. Lee, et al. ; Apoptosis 12, 1183 (2007), Application(s): WB using drosophila cell lysates, Abstract;

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