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RAIDD polyclonal antibody

 
ADI-AAP-270-C 25 µg 129.00 USD
 
ADI-AAP-270-E 100 µg 269.00 USD
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Product Specification

Alternative Name:CRADD, Caspase and RIP adaptor with death domain, RIP-associated protein with a death domain
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human RAIDD.
 
UniProt ID:P78560
 
GenBank ID:U79115
 
Species reactivity:Human, Rat
Hamster, Monkey
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:50)
Western Blot (1:500, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~24kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In borate buffered saline, pH 8.2, containing 25mM sodium borate, 100mM boric acid, 75mM sodium chloride, and 5mM EDTA (disodium salt).
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) also known as CRADD (caspase and RIP adapter with DD) contains a DD (death domain) and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNF-R1.
 
AAP-270 WB
Western blot analysis of human K562 cell lysate, probed with RAIDD pAb
AAP-270 IHC
Immunohistochemistry analysis of paraffin-embedded sections stained with RAIDD pAb. Peptide competition RAIDD is selectively increased in neurons in Alzheimer’s disease (right) in comparison to control (left).
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AAP-270 WB AAP-270 IHC

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