FADD, pAb



ADI-AAP-210-D	50 µg	190.00 USD

ADI-AAP-210-F	200 µg	360.00 USD

Product Specification

Alternative Name:	MORT1, Fas (TNFRSF6)-associated via death domain

Host:	Rabbit

Immunogen:	Synthetic peptide corresponding to a portion of human FADD.

UniProt ID:	Q13158

Application:	Immunocytochemistry Immunohistochemistry (paraffin sections) Western Blot (1:1000, ECL) Optimal conditions must be determined individually for each application.

Specificity:	Recognizes human, rat, and monkey FADD. Detects a band of ~28kDa by Western blot.

Purity Detail:	Peptide affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Long Term Storage:	-20°C

Miscellaneous/General:	Fas-associating death domain containing protein (FADD)/MORT1 serves as a signal transducer of Fas-induced apoptosis. Through its amino-terminal death effector domain (DED), FADD binds to cytosolic proteins such as TRADD, a cytosolic death domaincontaining protein that asssociates with the cytosolic portion of TNF receptor, or MACH/FLICE/caspase-8, a protease with sequence homology to ICE-CED-3 protease family, in order to transduce the death signal.

Western blot analysis: Lane 1: MW marker, Lane 2: HeLa.

IHC Analysis: Human kidney tissue stained with FADD, pAb at 10µg/ml.

IHC Analysis: Human placenta tissue stained with FADD, pAb at 10µg/ml.

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Product Literature References

Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli: T.R. Billiar, et al. ; J. Biol. Chem. 277, 38855 (2002), Application(s): ICC, WB using rat samples, Abstract;

B cell receptor cross-linking triggers a caspase-8-dependent apoptotic pathway that is independent of the death effector domain of Fas-associated death domain protein: A. Vazquez, et al. ; J. Immunol. 167, 733 (2001), Application(s): WB using human samples, Abstract;