| ADI-AAP-170-E | 100 µg | 319.00 USD |  |
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| Alternative Name: | Cyt c |
| Host: | Sheep |
| Isotype: | IgG |
| Immunogen: | Full length recombinant cytochrome C. |
| UniProt ID: | P62897 |
| Gene/Protein Identifier: | NP_031834 (RefSeq) |
| Species reactivity: | Human, Rat Dog, Rabbit |
| Applications: | IHC, IP, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:5,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~14kDa by Western blot. May be used in immunofluorescence applications with human and rat cells. |
| Purity Detail: | Affinity purified. |
| Formulation: | Liquid. In PBS containing 0.08% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Cytochrome c, which is a critical component of the electron transport chain, is a component of the functional apoptosome. Upon release from the mitochondria, cytochrome c binds to the adaptor proteins Apaf-1 and procaspase-9 to form a cytosolic apoptosome complex. This event results in activation of procaspase-9 and its subsequent cleavage and activation of caspase-3 leading to the degradation of a series of cellular substrates and subsequently cell death. |
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