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AIF (IN) polyclonal antibody

 
ADI-AAP-015-E 100 µg 301.00 USD
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Product Specification

Alternative Name:Apoptosis-inducing factor
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human AIF .
 
UniProt ID:O95831
 
GenBank ID:AAD16436
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (0.25-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~67kDa by Western blot.
 
Purity Detail:Ion exchange purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Apoptosis inducing factor (AIF) is a mitochondrial inter-membrane flavoprotein that is ubiquitously expressed both in normal tissues and in a variety of cancer cell lines. AIF is synthesized as a nonapoptogenic precursor in the cytoplasm and efficiently imported into the mitochondrial inter-membrane space. Mature AIF protein is normally confined to the mitochondrial inter-membrane space. In a variety of different apoptosis-inducing conditions AIF translocates through the outer mitochondrial membrane to the cytosol and to the nucleus. Extra-mitochondrial AIF induces nuclear chromatin condensation and large scale (~50kb) DNA fragmentation.
 
AAP-015 WB
Western blot analysis of human K562 cell lysates (A), rat (B), and mouse (C) heart tissue using AIF (IN) pAb at 1µg/ml.
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AAP-015 WB

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Apoptosis-inducing factor
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Apoptosis-inducing factor Polyclonal antibody
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