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Bag-1 monoclonal antibody (4A2)

ADI-AAM-400-E 100 µg 329.00 USD
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Product Specification

Alternative Name:Bcl-2 associated athanogene-1, BAG family molecular chaperone regulator 1, RAP46
Immunogen:Recombinant mouse Bag-1.
UniProt ID:Q60739
Species reactivity:Human, Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~28kDa (mouse and rat), ~31kDa (human) by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Bag-1 is a multifunctional Bcl-2-binding protein that lacks sequence homology with Bcl-2 and its related proteins, and functions to enhance the anti-apoptotic effects of Bcl-2. Bag-1 binds to the intracellular domain of the hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF) receptors, enhancing growth factor mediated protection from apoptosis. Bag-1 is known to modulate the chaperone activity of Hsc70/Hsp70, serving as a nucleotide exchange factor via binding to the ATPase domain of Hsc70/Hsp70. Bag-1 is known to promote cell survival through activation of the Raf-1 kinase.
Bag-1 monoclonal antibody (4A2) Western blot
Western blot analysis: Lane 1 Bag-1 (recombinant), lane 2 jurkate cell lysate; lane 3 U937 cell lysate, lane 4 NIH3T3 cell lysate and lane 5 PC12 cell lysate probed with Bag-1, mAb (4A2).
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Bag-1 monoclonal antibody (4A2) Western blot

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