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Mcl-1 monoclonal antibody (22)

 
ADI-AAM-241-E 100 µg 271.00 USD
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Product Specification

Alternative Name:Bcl-2-like protein 3
 
Clone:22
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human Mcl-1.
 
UniProt ID:Q07820
 
GenBank ID:L08246
 
Species reactivity:Human
 
Applications:WB
 
Application Notes:Detects a band of ~42-44kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Mcl-1 is a member of the Bcl-2 family that possesses anti-apoptotic activity. Mcl-1 is an immediate-early gene activated by the GMCSF as well as IL-3 signaling pathways and plays an important role in the viability response of these cytokines. Similar to all Bcl-2 family members, Mcl-1 contains BH1, BH2, and BH3 domains; however, unlike other members of this family, Mcl-1 has an extended N-terminal domain rich in PEST sequences, which probably accounts for the short half-life of this protein.
 
AAM-241 WB
Western blot analysis of LMW (1), HeLa (2), HeLa (HS) (3), Jurkat (4), and Jurkat (HS) (5), probed with Mcl-1 mAb (22).
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AAM-241 WB

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