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FADD monoclonal antibody (1F7)

 
ADI-AAM-212-E 100 µg 306.00 USD
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Product Specification

Alternative Name:MORT1, Fas (TNFRSF6)-associated via death domain
 
Clone:1F7
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human FADD.
 
UniProt ID:Q13158
 
Species reactivity:Human, Mouse
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~28kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Fas-associating death domain containing protein (FADD)/MORT1 serves as a signal transducer of Fas-induced apoptosis. Through its amino-terminal death effector domain (DED), FADD binds to cytosolic proteins such as TRADD, a cytosolic death domaincontaining protein that asssociates with the cytosolic portion of TNF receptor, or MACH/FLICE/caspase-8, a protease with sequence homology to ICE-CED-3 protease family, in order to transduce the death signal.
 
FADD monoclonal antibody (1F7) Western blot
Western blot probed with FADD mAb (1F7). Lane 1 FADD (recombinant) and cell lysates Jurkat (lane 2), Raji (lane 3), HeLa (lane 4), ZR75-1 (lane 5), A431 (lane 6), and HUC-Fm (lane 7).
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FADD monoclonal antibody (1F7) Western blot

Product Literature References

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis: Y. Estornes, et al.; Cell Death Dis. 9, 494 (2018), Abstract; Full Text
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death: E. Lafont, et al.; EMBO J. 36, 1147 (2017), Abstract; Full Text
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157: D. Rojas-Rivera, et al.; Cell Death Differ. 24, 1100 (2017), Abstract; Full Text
γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling: J. Chhibber-Goel, et al.; J. Biol. Chem. 291, 5971 (2016), Abstract; Full Text
CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis: Y. Zhao, et al.; J. Biol. Chem. 90, 22076 (2015), Application(s): Western Blot, Abstract;

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