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Caspase-9 monoclonal antibody (2-22)

 
ADI-AAM-149-C 25 µg 110.00 USD
 
ADI-AAM-149-E 100 µg 298.00 USD
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Product Specification

Clone:2-22
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human Caspase-9 protein (prodomain).
 
UniProt ID:P55211
 
GenBank ID:AAC50640
 
Species reactivity:Human
Monkey
 
Applications:IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (12.5µg/ml)
Western Blot (2µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.01mM PMSF and 50% glycerol.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
 
AAM-149-Antibody-Blot
ADI-AAM-149 IHC1
IHC Analysis: Human heart tissue stained with Caspase-9, mAb (2-22) at 10µg/ml.
ADI-AAM-149 IHC2
IHC Analysis: Human spleen tissue stained with Caspase-9, mAb (2-22) at 10µg/ml.
ADI-AAM-149 IHC3
IHC Analysis: Human uterus, vessels tissue stained with Caspase-9, mAb (2-22) at 10µg/ml.
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AAM-149-Antibody-Blot ADI-AAM-149 IHC1 ADI-AAM-149 IHC2 ADI-AAM-149 IHC3

Product Literature References

PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2: R.A. Schmid, et al. ; Oncogene 22, 5427 (2003), Application(s): WB using human samples, Abstract;

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