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Caspase-4 monoclonal antibody (4B9)

 
ADI-AAM-114-E 100 µg 313.00 USD
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Product Specification

Clone:4B9
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human caspase-4 (N-terminal fragment).
 
UniProt ID:P49662
 
GenBank ID:HSU28014
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~45kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
 
ADI-AAM-114 WB
Western blot analysis of caspase-4 probed with Caspase-4, mAb (4B9). Lane 1: TXp20 (recombinant); Lane 2: U937 cell extract; Lane 3: HL60 cell extract; Lane 4: HUC-Fm cell extract; Lane 5: PC12 cell extract.
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ADI-AAM-114 WB

Product Literature References

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signaling: N. Kayagaki, et al.; Nature 526, 666 (2015), Application(s): Pyroptosis of innate human immune cells, Abstract;
GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses: Y. Hotokezaka, et al.; Cell Death Dis. 6, e1719 (2015), Abstract; Full Text
Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer: J.S. Carew, et al.; Cell Death Dis. 4, e728 (2013), Abstract; Full Text

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