Bcl-xL, mAb (2H12)

Purity Detail:	Ascites.

Formulation:	Liquid. In PBS containing 0.08% sodium azide.

Clone:	2H12

Isotype:	Mouse IgG2a

Immunogen:	Synthetic peptide corresponding to the sequence near the N-terminus of human Bcl-xL.

Specificity:	Recognizes human, mouse and rat Bcl-xL. Detects a band of ~28kDa by Western blot.

Application:	Western Blot (1-5µg/ml, ECL) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	The Bcl-2 family of proteins regulate the intrinsic apoptotic pathway and are characterized by the sharing of at least one of four conserved Bcl-2 Homology (BH) domains. Bcl-2 family members function as either pro- or anti-apoptotic factors, and are generally categorized into three groups based on structural homology and function. Bcl-2-like proteins (Bcl-2, Bcl-xL, Bcl-w, A1, and Mcl-1) are pro-survival. Pro-apoptotic members can be sub-divided into two groups: the multi-BH domain group, including Bax, Bak, and Bok; and the more numerous and diverse BH3-only group, which includes Bim, Bad, and Bid.