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XIAP monoclonal antibody (2F1)

 
ADI-AAM-050-E 100 µg 281.00 USD
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Product Specification

Alternative Name:X-chromosome-linked inhibitor of apoptosis protein
 
Clone:2F1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human XIAP.
 
UniProt ID:P98170
 
GenBank ID:AAC50373
 
Species reactivity:Human, Mouse
 
Applications:IHC, IP, WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~55kDa by Western blot.
 
Purity Detail:Protein A affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:XIAP (X-linked inhibitor of apoptosis) belongs to the IAP (inhibitors of apoptosis) family, which is characterized by one or more BIR (baculovirus IAP repeat) domains. These proteins have multiple biological functions that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. XIAP functions by direct binding and inhibition of several caspases, including caspase-3, caspase-7 and caspase-9.
 
AAM-050 WB
Western blot analysis of Jurkat (1), Raji (2), HeLa (3), WR19L (4) and PC12 (5) cells, probed with XIAP mAb (2F1).
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AAM-050 WB

Product Literature References

Silibinin sensitizes human glioma cells to TRAIL-Mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin: K. Choi, et al. ; Cancer Res. 67, 8274 (2007), Application(s): WB using human cell lysates, Abstract;
Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia: P.H. Chan, et al. ; J. Cereb. Blood Flow Metab. 23, 1010 (2003), Application(s): IHC using mouse samples, Abstract;
Role of Smac in human leukaemic cell apoptosis and proliferation: A.C. Newland, et al. ; Oncogene 22, 1589 (2003), Application(s): IP using human samples, Abstract;
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway: K. Matsumoto, et al. ; EMBO J. 18, 179 (1999), Application(s): IP using human samples, Abstract;
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway: K. Matsumoto, et al. ; EMBO J. 18, 179 (1999), Application(s): IP using monkey samples, Abstract;

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