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Osteoprotegerin monoclonal antibody (98A1071)

 
ADI-AAM-020-E 100 µg 291.00 USD
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Product Specification

Alternative Name:OPG, TNFRSF 11B, Osteoclastogenesis inhibitory factor
 
Clone:98A1071
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human OPG (osteoprotegerin).
 
UniProt ID:O00300
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml AP, 1µg/ml ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~55kDa & ~110kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Osteoprotegerin (OPG) is a secreted glycoprotein belonging to the TNF receptor (TNF-R) superfamily that functions as a decoy receptor for RANK-Ligand (RANKL/OPGL). Unlike other TNF-Rs, OPG lacks a membrane-anchoring hydrophobic domain and lacks any apparent cell-associated signaling capability. OPG secreted by osteoblasts competes with RANK (expressed on osteoblast precursors) for binding to RANKL, blocking osteoclastogenesis and increasing bone density.
 
AAM-020 WB
Western blot analysis of Daudi cell lysate with OBG mAb at 1µg/ml.
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AAM-020 WB

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