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Osteoprotegerin monoclonal antibody (98A1071)

 
ADI-AAM-020-E 100 µg 306.00 USD
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Product Specification

Alternative Name:OPG, TNFRSF 11B, Osteoclastogenesis inhibitory factor
 
Clone:98A1071
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human OPG (osteoprotegerin).
 
UniProt ID:O00300
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml AP, 1µg/ml ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~55kDa & ~110kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Osteoprotegerin (OPG) is a secreted glycoprotein belonging to the TNF receptor (TNF-R) superfamily that functions as a decoy receptor for RANK-Ligand (RANKL/OPGL). Unlike other TNF-Rs, OPG lacks a membrane-anchoring hydrophobic domain and lacks any apparent cell-associated signaling capability. OPG secreted by osteoblasts competes with RANK (expressed on osteoblast precursors) for binding to RANKL, blocking osteoclastogenesis and increasing bone density.
 
Osteoprotegerin monoclonal antibody (98A1071) Western blot
Western blot analysis of Daudi cell lysate with OBG mAb at 1µg/ml.
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Osteoprotegerin monoclonal antibody (98A1071) Western blot

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