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MAGE-1 (human), (recombinant)

 
ADI-908-287-010 10 µg 370.00 USD
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Product Specification

Alternative Name:Melanoma-associated antigen 1
 
Source:Produced in E. coli.
 
UniProt ID:P43355
 
Formulation:Liquid. In 50mM TRIS-HCl, pH 7.5 with 10mM L-glutathione (reduced).
 
Purity Detail:Glutathione sepharose affinity purified.
 
Applications:ELISA, WB
Activity assay
 
Application Notes:Western blot control.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Human malignant neoplasms carry rejection antigens recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens coded by the MAGE family of genes includes common melanoma associated antigens (MAAs) expressed by melanomas and primary glial brain tumors. Because MAGE-1 expression occurs in a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas) but not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
 

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