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Cathepsin D (human), (recombinant) (His-tag)

ADI-908-241-010 10 µg Inquire for pricing
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Product Specification

Source:Produced in E. coli. Human cathepsin D is fused at the N-terminus to a His-tag.
UniProt ID:P07339
Formulation:Liquid. In 50mM TRIS-Acetate, pH 7.5, containing 1mM EDTA and 20% glycerol.
Purity:≥90% (SDS-PAGE)
Purity Detail:Purified by nickel column.
Applications:ELISA, WB
Inhibition assay
Application Notes:Western blot control.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:Cathepsin D is an aspartyl endoproteinase distributed to the lysosome that participates in the degradation of proteins at an acidic pH. The proteolytic activity of Cathepsin D is known to play a role in antigen processing, cell proliferation and tissue renewal, and prohormone activation. Synthesized as a 54 kDa precursor, Cathepsin D is then proteolytically processed to an intermediate 48 kDa single chain which matures into more stable 34 kDa (heavy chain) and 14 kDa (light chain) subunits. As an estrogen-regulated lysosomal protease, overexpression of Cathepsin D in breast cancer is known to correlate with increased metastatic potential and shorter patient survival.

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