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Cathepsin D (human), (recombinant) (His-tag)

 
ADI-908-241-010 10 µg 365.00 USD
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Product Specification

MW:~48kDa
 
Source:Produced in E. coli. Human cathepsin D is fused at the N-terminus to a His-tag.
 
UniProt ID:P07339
 
Formulation:Liquid. In 50mM TRIS-Acetate, pH 7.5, containing 1mM EDTA and 20% glycerol.
 
Purity:≥90% (SDS-PAGE)
 
Purity Detail:Purified by nickel column.
 
Applications:ELISA, WB
Inhibition assay
 
Application Notes:Western blot control.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Cathepsin D is an aspartyl endoproteinase distributed to the lysosome that participates in the degradation of proteins at an acidic pH. The proteolytic activity of Cathepsin D is known to play a role in antigen processing, cell proliferation and tissue renewal, and prohormone activation. Synthesized as a 54 kDa precursor, Cathepsin D is then proteolytically processed to an intermediate 48 kDa single chain which matures into more stable 34 kDa (heavy chain) and 14 kDa (light chain) subunits. As an estrogen-regulated lysosomal protease, overexpression of Cathepsin D in breast cancer is known to correlate with increased metastatic potential and shorter patient survival.
 

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