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Myeloperoxidase fluorometric detection kit

 
ADI-907-029 500 tests 526.00 USD
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  • Fast homogenous assay
  • Suitable for High Throughput Screening
  • Monitor multiple time points to follow kinetics
  • Results in 30 to 60 minutes
The Myeloperoxidase fluorometric detection kit is a one-step no wash homogeneous activity assay that is adaptable to HTS applications. This kit offers highly sensitive fluorescent detection and the ability to monitor multiple time points to follow the kinetics of MPO activity.
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Product Specification

Alternative Name:MPO
 
Sensitivity:

0.00195 units/ml
 

 
Applications:Fluorescence microscopy
 
Application Notes:For the measurement of Myeloperoxidase activity in cells and tissue from any species.
 
Species reactivity:Species independent
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Kit/Set Contains:Assay buffer concentrate, Detection Reagent, Hydrogen peroxide, Myeloperoxidase enzyme
 
Scientific Background:Myeloperoxidase (MPO) is synthesized as a single chain precursor, which is then processed into a tetramer consisting of 2 light chains and 2 heavy chains. In response to microbial invasion, MPO is released from the cytoplasmic granules of neutrophils into the extracellular space and phagosome, where it generates hypohalous acids that have a strong microbicidal effect. Myeloperoxidase can be used as a marker of airway inflammation caused either by disease, such as asthma, or by environmental irritants.
 
UniProt ID:P05164
 

Product Literature References

Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn: A. Ahmad, et al.; Burns 43, 1021 (2017), Abstract;
Cepharanthine mitigates lung injury in lower limb ischemia–reperfusion: M.C. Kao, et al.; J. Surg. Res. 199, 647 (2015), Application(s): Activity detected in lung tissue in rats, Abstract;
Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats: M.C. Kao, et al.; Cytokine 76, 442 (2015), Application(s): Activity detected in lung tissue in rats, Abstract;
Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury: N. Cho, et al.; J. Neuroinflammation 9, 134 (2012), Application(s): Activity detected in mouse spinal cord extracts, Abstract; Full Text
Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury: P. Mukhopadhyay, et al.; Free Radic. Biol. Med. 50, 179 (2011), Application(s): Activity detected in mouse myocardial tissue extracts, Abstract;

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