Synthetic peptide corresponding to the sequence near the N-terminus of human Neurotensin 1 Receptor (NTS1).
UniProt ID:
P30989
Species reactivity:
Human, Mouse, Rat
Crossreactivity:
Predicted species reactivity based on epitope sequence homology: bovine, dog, rhesus macaque.
Applications:
IHC, WB
Application Notes:
Detects a band of ~40kDa. by Western blot.
Purity Detail:
Peptide affinity purified.
Formulation:
Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Handling:
Keep on ice at all times.
Shipping:
Shipped on Blue Ice
Long Term Storage:
-20°C
Scientific Background:
The subtype 1 neurotensin receptor (NTS1) is a seven-transmembrane domain containing G protein coupled receptor (GPCR) that mediates most of the known effects of neurotensin. NTS1 activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems, mediating such functions as hypotension, hyperglycemia, hypothermia, antinociception, and the regulation of intestinal motility and secretion. NTS1 signaling is primarily mediated via coupling to Gq/G11 family G proteins, although coupling of NTS1 through Gs and Gi/o family proteins has been shown to modulate both adenylate and guanylate cyclase activity.
Manufacturer:
Manufactured by Proteimax.
Western blot analysis: MW marker (1) and 20µg rat kidney extract (2) probed with Neurotensin Receptor 1 (NTS1) pAb.
