α-Actinin, mAb (7A4)



ADI-905-891-100	100 µl	235.00 USD

Product Specification

Alternative Name:	ACTN1

Purity Detail:	Protein G-affinity purified.

Formulation:	Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Clone:	7A4

Isotype:	Mouse IgG2a

Immunogen:	Recombinant human α-actinin (aa 650-893).

Specificity:	Recognizes human α-Actinin. Detects a band of ~98kDa (full length) by Western blot.

Application:	Western Blot (1:100,000) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

Western blot analysis of HeLa cell lysate transfected with human alpha-actinin gene expression vector, probed with α-Actinin (ACTN1) mAb (7A4) at 1:100,000 dilution.

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