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Jnk1 monoclonal antibody (1C2)

 
ADI-905-862-100 100 µl 356.00 USD
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Product Specification

Alternative Name:c-Jun N-terminal kinase 1, SAP kinase 1c, SAPK1c, MAP kinase 8, MAPK8
 
Clone:1C2
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Recombinant human Jnk1 (aa 1-384).
 
UniProt ID:P45983
 
Species reactivity:Human, Mouse
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~45kDa (full length) by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
 
905-862 WB
Western blot analysis: NIH/3T3 cell lysate probed with Jnk1 mAb (1C2) at 1:1000 dilution.
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905-862 WB

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