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Sonic hedgehog monoclonal antibody (10H6)

 
ADI-905-860-100 100 µl 399.00 USD
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Product Specification

Alternative Name:SHH
 
Clone:10H6
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human SHH (sonic hedgehog) (aa 24-197).
 
UniProt ID:Q15465
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~50kDa (full length) by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Sonic Hedgehog (SHH) is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.
 
905-860 WB
Western blot analysis of HEK-293T cell lysates, transfected with human SHH expression vector, probed with SHH mAb (10H6) at 1:2000.
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905-860 WB

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