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PDX1 monoclonal antibody (2A12)

 
ADI-905-857-100 100 µl 366.00 USD
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Product Specification

Clone:2A12
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human PDX1 (aa 1-283).
 
UniProt ID:P52945
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:20,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~31kDa (full length) by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Pdx1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. It is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in PDX1 gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
 
905-857 WB
Western blot analysis of 293 cell lysates nontransfected (lane 1) or transfected (lane 2) with PDX1 expression vector, probed with PDX1 mAb (2A12) at 1:20000 dilution.
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905-857 WB

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