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Amyloid β A4 (CT, 1-42) monoclonal antibody (8G7)

 
ADI-905-804-100 100 µg 356.00 USD
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Replaces Prod. #: ALX-804-412

Product Specification

Clone:8G7
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to aa 1-42 of amyloid β A4.
 
UniProt ID:P05067
 
Species reactivity:Human
 
Crossreactivity:Does not cross react with β A4 (1-40).
 
Applications:ELISA, ICC, WB
 
Recommended Dilutions/Conditions:ELISA (0.05µg/ml)
Immunocytochemistry (0.1-1.0µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~4kDa by Western blot.
 
Purity Detail:Thiophilic adsorption and size exclusion chromatography purified.
 
Formulation:Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.
 
Reconstitution:Reconstitute with 1ml water (15 minutes at room temperature).
 
Use/Stability:Stable at -80°C up to 1 year, at 4°C up to 3 months.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The β-amyloid peptide (β A4), proteolytically released from the amyloid precursor protein (APP), provides the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by α-secretase or alternatively by β-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-α and S-APP-β, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by γ-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/ nicastrin-mediated γ-secretase processing of C99 releases the amyloid β proteins, amyloid-β 40 (Aβ40) and amyloid-β 42 (Aβ42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, γ-CTF(50), γ-CTF(57) and γ-CTF(59).
 
Technical Info/Product Notes:Application Note:
Analysis of the Effect of Aggregated β-Amyloid on Cellular Signaling Pathways Critical for Memory in Alzheimer’s disease
 
ADI-905-804 WB
Western blot analysis of (1) β A4 (1-40), (2) β A4 (1-42), and (3) β A4 (1-43), probed with 2µg/ml of Amyloid β A4 (42) mAb (8G7).
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ADI-905-804 WB

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