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PGD2 receptor (DP1) polyclonal antibody

 
ADI-905-800-100 100 µg 281.00 USD
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Product Specification

Alternative Name:Prostaglandin D2 receptor, PTGDR
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat PGD2 receptor (DP1).
 
UniProt ID:Q9R261
 
Species reactivity:Rat
 
Crossreactivity:Predicted species reactivity based on epitope sequence homology: mouse.
 
Applications:ELISA, IHC, WB
 
Application Notes:Suitable for membrane-based ELISA.
Predicted MW of ~40kDa.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The conversion of arachidonic acid to prostaglandin H2 (PGH2) by cyclooxygenase (COX) enzymes is the first step in the synthesis of prostanoids. Prostaglandin D2 (PGD2) is synthesized from PGH2 by the action of PGD synthase, and its actions in vasodilation and platelet activation are mediated via activation of two identified G-protein coupled receptors (GPCRs): DP1 and DP2 (formerly CRTH2). Both DP1 and DP2 receptors are coupled to Gs alpha subunits, resulting in increased adenylyl cyclase activity and cAMP production upon agonist binding. DP1 receptor is expressed moderately in the ileum and weakly in the lung, stomach, and uterus of mice, and weakly in the small intestine of humans. In rodents, expression of PGD synthase and the DP1 receptor is seen in the leptomeninges, where it is believed they play a role in the induction of sleep. The DP1 receptor may also oppose DP2-mediated activation of basophils, eosinophils, and Th2 cells.
 
Manufacturer:Manufactured by Proteimax.
 
905-800 WB
Western blot analysis: MW marker (1) and 20µg rat brain extract (2) probed with PGD2 Receptor (DP1) pAb at 4.9µg/ml.
905-800 m ELISA
Membrane ELISA: Lewis rat striatum membranes (5µg/well) were treated with 1μM concentrations of agonist (PGD2/BW245C) and probed with PGD2 Receptor (DP1) pAb (1:250 to 1:2000 of a 1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=2).
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905-800 WB 905-800 m ELISA

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