Muscarine receptor M₁, pAb



ADI-905-796-100	100 µg	270.00 USD

Product Specification

Purity Detail:	Peptide affinity purified.

Formulation:	Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.

Immunogen:	Synthetic peptide corresponding to the sequence near the N-terminus of rat muscarine receptor M₁.

Source/Host:	From rabbit.

Specificity:	Recognizes rat muscarine receptor M₁. Predicted MW of ~51kDa.

Application:	Western Blot Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	The pharmacologic activity of acetylcholine (ACTH) is mediated by the ionotropic nicotinic receptor or via metabotropic muscarinic receptors. Five known acetylcholine (muscarinic) receptors (M1-M5) are variably expressed in the central nervous system and periphery, mediating motor control, thermoregulation, memory, smooth muscle contraction, glandular secretion, and cardiac function. Although the physiology of the five mammalian muscarinic receptor homologs does not differ significantly in their affinities to a variety of agonists (ACTH, muscarine) and antagonists (e.g., atropine), they can be divided into two sub-groups (M1/M3/M5 and M2/M4) based on G alpha subunit coupling preferences. M1/M3/M5 receptors signal primarily via Gq/11 alpha subunits to stimulate phospholipase C, whereas M2/M4 receptors couple to Gi/o alpha subunits to inhibit adenylyl cyclases and cAMP production. Modulation of muscarinic receptor activity holds promise for the treatment of psychiatric and neurological disorders including schizophrenia and Alzheimer's disease.

Manufacturer:	Manufactured by Proteimax.