Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Bradykinin receptor B1 polyclonal antibody

 
ADI-905-787-100 100 µg 323.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-SA632

Product Specification

Alternative Name:B1BKR
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat bradykinin receptor B1.
 
UniProt ID:P97583
 
Species reactivity:Mouse, Rat
 
Applications:ELISA, IHC, WB
 
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~38kDa. observed by Western blot MW species (~ 38kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both members of the seven-transmembrane domain-containing G-protein coupled receptor (GPCR) family. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following tissue injury or during inflammation. The B2 receptor displays high affinity for BK and Lys-BK peptide agonists, while the B1 receptor displays highest affinity to des-Arg9-BK and des-Arg10-kallidin. Both receptors are best characterized as signaling via coupling to Gq alpha subunits (particularly Gq/11), leading to activation of phospholipase C beta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.
 
Manufacturer:Manufactured by Proteimax.
 
905-787 WB
Western blot analysis: MW marker (1) and 25µg rat heart extract (2) probed with Bradykinin Receptor (B1) pAb at 0.75µg/ml.
905-787 m ELISA
Membrane ELISA: Lewis rat heart membranes (5µg/well) were treated with 1 μM concentrations of agonist (BK-1-8) and probed with Bradykinin Receptor (B1) pAb (1:10 to 1:150 of a 0.1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=6).
Please mouse over
905-787 WB 905-787 m ELISA

Related Products

Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) 

ELISA, IHC, WB | Print as PDF
 
ADI-SAB-300-J 1 ml 118.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,