Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Adrenergic receptor α1b polyclonal antibody

 
ADI-905-785-100 100 µg 291.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:ADRA1B, AR α-1b
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of rat adrenergic receptor α1b.
 
UniProt ID:P15823
 
Species reactivity:Rat
 
Crossreactivity:Predicted species reactivity based on epitope sequence homology: human, mouse, bovine, rhesus macaque, rabbit, wild boar, dog.
 
Applications:ELISA, IHC, WB
 
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~56kDa. Higher MW species also observed by Western blot which reflect post-translational modification of the receptor.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Adrenergic receptors mediate the hormone and neurotransmitter functions of adrenaline and noradrenaline. Adrenoreceptors function in peripheral tissues and the central nervous system to regulate numerous vascular, metabolic, and neurological functions, and are the target for many therapeutically relevant drugs including those for the treatment of hypertension, asthma, benign prostatic hypertrophy, and depression. Adrenoreceptors are classified by three types (α1, α2, and β) and multiple subclasses based on pharmacological and molecular characteristics. The α1 family consists of three receptor subtypes (α1a, 1b, 1d) which primarily signal via Gq/11 alpha subunits to stimulate Phospholipase C and increase intracellular calcium. In contrast, the three α2 family receptor subtypes (α2a, 2b, 2c) signal via Gi/o alpha subunits to inhibit adenylyl cyclase activity, increase potassium transport, inhibit calcium conductance, and stimulate phospholipase A2. α1b adrenergic receptor mRNA expression in human tissues is highest in the spleen, kidney, and fetal brain. The α2a receptor is most highly expressed in human brain, spleen, and kidney, and is a species orthologue of the α2d receptor expressed similarly in rat, mouse, and cow.
 
Manufacturer:Manufactured by Proteimax.
 
905-785 WB
Western blot analysis: MW marker (1) and 20µg rat brain extract (2) probed with Adrenergic Receptor (alpha 1b) pAb at 5.9µg/ml.
905-785 m ELISA
Membrane ELISA: Lewis rat striatum membranes (5µg/well) were treated with 1 μM concentrations of agonist (UK14304) and probed with Adrenergic Receptor (alpha 1b) pAb (1:250 to 1:2000 of a 1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=4).
Please mouse over
905-785 WB 905-785 m ELISA

Related Products

Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) 

ELISA, IHC, WB | Print as PDF
 
ADI-SAB-300-J 1 ml 118.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,