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Septin 5/Cdcrel-1 monoclonal antibody (SP18)

 
ADI-905-781-100 100 µg 258.00 USD
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Product Specification

Clone:SP18
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Immunoprecipitate of human brain.
 
UniProt ID:Q99719
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~43kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Septin 5 (Sept5/CDCrel-1) is a member of the Septin family of cytoskeletal GTPases. Septin 5 expression is primarily associated with synaptic vesicles in cells of the nervous system where it acts to inhibit exocytosis, although it has also been characterized as an inhibitor of aggregation and release of storage granules in platelets. Phosphorylation of Septin 5 at Ser17 by Cdk5-p35 has been shown to mediate the interaction of Septin 5 with the SNARE protein Syntaxin-1A, regulating neurotransmitter release. Targeted disruption of the Septin 5 gene in mice failed to produce an obvious neurological phenotype, indicating its loss may be overcome by functional redundancy of other septins. Septin 5 is one of several Parkin (an E3 ubiquitin ligase) associated substrates whose accumulation results in cellular toxicity related to the onset of autosomal recessive Parkinson Disease.
 
905-781 WB
Western blot analysis of MW marker (1) and human brain extract (2), probed with Septin 5/CDCrel-1 mAb (SP18).
905-781 IHC
Immunohistochemistry analysis of human brain, cerebellum tissue stained with Septin 5/Cdcrel-1 mAb (SP18) at 20µg/ml.
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905-781 WB 905-781 IHC

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