| Host: | Rabbit |
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| Immunogen: | Synthetic dimethyl-peptide corresponding to human Histone H3. |
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| UniProt ID: | P68431 (Histone H3.1), Q71DI3 (Histone H3.2), P84243 (Histone H3.2) |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Human, Mouse
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| Crossreactivity: | Weakly cross-reacts with rat, bovine and dog Histone H3 (dimethyl-Lys9). |
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| Applications: | WB
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| Purity Detail: | Peptide affinity purified. |
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| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. |
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| Regulatory Status: | RUO - Research Use Only |
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