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[pSer1981]ATM polyclonal antibody

 
ADI-905-774-100 100 µg 308.00 USD
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Product Specification

Alternative Name:Ataxia telangiectasia mutated
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of human ATM phosphorylated at Ser1981.
 
UniProt ID:Q13315
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~351kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:ATM (Ataxia telangiectasia mutated) is a 350 kDa protein that has ionizing radiation (IR)-inducible protein kinase activity. ATM is mutated in Ataxia telangiectasia (AT) which is an autosomal recessive disorder characterized by acute cancer predisposition, telangiecstasia, sensitivity to ionizing radiation, and neuronal degeneration. ATM mediates efficient induction of a signaling network, which is responsible for the repair of the DBS damage and for cellular recovery and survival.
 
905-774 WB
Western blot analysis of ATM (pSer1981). Lane 1: MW, Lane 2: HeLa, Lane 3: γ-irradiated HeLa.
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905-774 WB

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