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Chk1 monoclonal antibody (2G1D5)

 
ADI-905-770-100 100 µg 248.00 USD
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Product Specification

Alternative Name:Checkpoint kinase 1
 
Clone:2G1D2
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant human Chk1.
 
UniProt ID:O14757
 
Species reactivity:Human, Mouse, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~55kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The DNA damage checkpoint is a signal transduction pathway that has the ability to delay entry into mitosis. When DNA is damaged, the Check point kinases (CHKs) are known to act downstream of ATM to elicit appropriate responses such as cell cycle arrest. Chk1, for instance, is activated by ATM phosphorylation of serines 123, 178, 278, and 292 of the S phase-promoting cdc25A phosphatase and accelerates IR (ionizing radiation)induced degradation of cdc25A.
 
905-770 WB
Western blot analysis of CHK1 using HeLa and NIH/3T3 cell extracts. Lane 1: Molecular Weight Markers, Lane 2: HeLa, Lane 3: NIH/3T3.
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905-770 WB

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